Method of making cosmetic, pharmaceutical, and dermatological compositions and compositions made according to the method

ABSTRACT

The invention concerns cosmetic and/or pharmaceutical and/or dermatological compositions and methods for preparing them. The composition is characterized in that it comprises a mixture called base mixture, consisting of a liquid extracted from a mixture (M) of tomatoes and apples once the spontaneous chemical reaction initiated by the mixture of the two crushed plants is completed. The invention is applicable to skin care.

This application is a 371 of PCT/FR98/00362, filed Feb. 24, 1998.

The present invention relates to in particular cosmetic and/orpharmaceutical and/or dermatological compositions intended in particularto promote the care of the skin. It also relates to the method ofmanufacture of such compositions.

At all times, one has sought to improve the aspect of the skin and inparticular to delay or to eliminate the signs of its ageing. This ageingis reflected among others in the appearance of wrinkles and a loss offirmness of the skin due to a natural slowing down of the renewal of theliving cells constituting this skin. The generally proposed solution isto eliminate the dead cells building up at the surface of the skin whilepromoting its cellular renewal.

The proposed cosmetic compositions are however most often based uponsynthetic hence non-natural chemical products of which in addition themanufacture is complex and costly. The treatment of the skin however isnot of aesthetic character only.

Thus acne and the lesions it causes originate from sebaceous glandsassociated with the pilose follicles in particular on the face, theback, the chest. These glands contain cells which secrete a mixture inparticular containing triglycerides, fatty acids called “sebum”. Inacne, the sebum secretions are increasing, the ducts of the sebaceousglands are thickening and produce black points or comedos andinflammations appear about the sebaceous glands.

The main treatments known for acne either are not really effective(various gels and ointments) or exhibit serious inconveniences whetherthey are antibiotics (absorption of antibiotics for a long durationthrough oral or local route, the latter mode risking to create bacteriaresistant to the antibiotics), or the retinoids (compounds closelyrelated to the vitamin A which are administered in a hospitalenvironment only and have incidences on the lever).

The eczema is as to it an inflammatory state of the skin characterizedby groups of vesicular lesions of variable sizes. The known treatmentsare generally based upon steroids and/or antibiotics which are medicineswhich have sometimes serious inconveniences.

Psoriasis and parapsoriasis are pathological pictures which appear onany portion whatsoever of the surface of the body and which even maycover it entirely. The seriousness of the lesions depends on both theextension and the depth at which the psoriasic process affects thedermic layers. An important point of the pathology of psoriasis is thatthe regeneration of the epidermis is much quicker in the case ofpsoriasis than for a normal skin (3-4 days instead of 27 days).

Although the disease is known for a long time, the known therapeutics(ultraviolets, tars, dithranol—which should not be put in contact withthe healthy skin—, steroids) are very little efficient and/or verypenalizing for the patients.

In a both cosmetic and pharmaceutical field, the acids of fruits(alpha-hydroxy acids) which belong to a group of substances extractedfrom natural products such as citric acid (extracted from fruits), malicacid (extracted from the apple), lactic acid (extracted from milk)assume an increasing importance.

Thus they would be efficient in the treatment of various diseases of theskin, among which acne, in the fight against ageing due to the sun(heliodermy) and for the rejuvenation and the improvement of the aspectof the skin (removal of the wrinkles, increase of the freshness and ofthe tenacity of the skin).

Numerous pharmaceutical and cosmetic special products based upon acidsof fruits are existing and new ones are appearing regularly.

However the use of these compounds and of compounds closely related tothe vitamin A as chemical compositions exhibits the inconvenience ofnon-negligible or significant secondary effects.

The invention has as its object to cope with the foregoinginconveniences by proposing in particular cosmetic and/or pharmaceuticalcompositions based upon usual alimentary plants.

For that purpose, the invention proposes a composition characterized inthat it comprises a mixture called basic mixture consisting of theliquid extracted from a mixture M of tomatoes and apples, once thisspontaneous reaction initiated by the mixture of both plants in crushedform has finished.

According to another characteristic of this composition, the mixture Min addition comprises a gelling or thickening agent and/or an emollientagent.

Preferably this gelling or thickening agent will consist of peaches orpersimmons and this emollient agent will consist of cucumbers.

When the mixture M does not comprise any gelling agent or emollientagent, it comprises apples and tomatoes with approximately equalweights.

When the mixture M comprises peaches or persimmons as a gelling orthickening agent or cucumbers as an emollient agent, it comprisesbetween 30 and 35% of peaches or persimmons, between 30 and 35% ofapples and about 30% of tomatoes as percentages by weight with respectto the weight of the final mixture (M).

Preferably it comprises between 25 and 30% of peaches or persimmons,between 20 and 25% of apples, between 20 and 25% of tomatoes and between25 and 30% of cucumbers as percentages by weight with respect to theweight of the final mixture M.

According to another characteristic of the composition according to theinvention, one adds a tenderizing or lysing agent to the said basicmixture.

This tenderizing or lysing agent will be more particularly selected inthe group constituted by papaw, papain, chimopapain, trypsin, pineapple,latex of the fig tree or pepsin.

The preferred tenderizing or lysing agent of the invention is papaw. Inthis case one adds about one third by weight of papaw and about twothirds by weight of the said basic mixture.

The compositions according to the invention may in addition contain anacidifying agent. A preferred acidifying agent is lemon juice.

According to another characteristic of the composition according to theinvention, one adds an irritating agent to the said basic mixture.

A preferred irritating agent is the cooking water of paprikas or greenpimentos.

According to another characteristic of the composition according to theinvention, one adds to the said basic mixture a mixture being both skinprotecting since comprising substances acting against free radicals suchas the vitamin C, the vitamin E, the beta-carotene, and skin-nutritivesince comprising vitamins A, B, PP, amino-acids, carbohydrates, purins,fatty acids, calcium and oligo-elements such as iron, copper, manganese,sulphur, phosphorus, diode and possibly phospholipids.

In this alternative embodiment of the invention, the preferrednutritious or nutritive and protecting medium consists of cabbage juiceor of the water of cooking, in preferably slightly mineralized water, ofcabbages, preferably of green cabbages, possibly in admixture with juicefrom the cooking water of other plants.

More preferably, the nutritious medium consists of the water of cooking,preferably in slightly mineralized water, either of green cabbages or ofa mixture in equal proportions by weight of green cabbages and of greensalads with thick leaves such as lettuce.

In this case, one adds to one volume of the composition of the inventionwithout any protecting and nutritive agent, three volumes of the saidcooking water.

All these compositions of the invention may be used for the manufactureof a cosmetic and/or pharmaceutical composition intended to promote thecare of the skin.

They may also be used for the manufacture of a cosmetic and/orpharmaceutical composition for the treatment of acne, of seborrhea, ofpsoriasis and of eczema.

In particular the invention proposes a bodily lotion for regeneratingand making firmer the skin, which is characterized in that one adds tothe said basic mixture or to the basic mixture admixed with a lysing ortenderizing agent, preferably papaw, the nutritious medium containingvitamins A, B, C, D, E, PP, amino-acids, calcium and oligo-elements suchas iron, copper, manganese, sulfur, phosphorus, iode etc. and possiblyan acidifying agent, preferably lemon juice.

A particularly preferred bodily lotion consists of one volume of thesaid basic mixture or of the said basic mixture admixed with papaw andof three volumes of the said cooking water and possibly of lemon juice.

Another subject of the invention is a cosmetic composition for theregeneration and the making firmer of the skin, the preventing of thewrinkles and the attenuation of the existing wrinkles, characterized inthat it contains the said basic mixture or the said basic mixtureadmixed with a tenderizing or lysing agent, preferably with papaw and athickener and/or a preservative and/or water and/or fats and/orhydrating fats and/or water/fats emulsifiers, cosmetically acceptablefor an application as a cream or as a mask.

Another subject of the invention is a lotion improving the tolerance tothe sun when applied before an exposure to the sun and alleviating thepain caused by an excessive exposure to the sun when applied after theexposure to the sun, characterized in that one adds to the so-calledbasic mixture or so-called basic mixture admixed with a tenderizing orlysing agent, preferably papaw, an agent containing compounds of thevitamin A such as vitamin A and the provitamin A, a nutritious mediumcontaining vitamins A, B, C, D, E, PP, calcium and oligo-elements andoptionally fat and/or water/fat emulsifiers.

In a preferred lotion of the invention improving the tolerance to thesun and alleviating the pain in case of excessive exposure to the sun,the agent containing compounds of the vitamin A consists of carrotjuice.

A more preferred lotion is a lotion in which the said nutritive mediumconsists of the water of cooking, in preferably slightly mineralizedwater, of a mixture in equal proportions by weight of beetroots, greencabbages and spinaches and the said fat is raisin-seed oil.

A more particularly preferred lotion of the invention improving thetolerance to the sun and alleviating the pain in case of excessiveexposure to the sun consists in equal proportions by volume of the saidmixture denoted here as a basic mixture B admixed or not with a lysingagent or with an acidifying agent, of the said cooking water, to whichmixture (B) one adds 20% by volume, with respect to the volume of themixture (B), of carrot juice or of green cabbage juice and possibly ofthe fat and of the water-fat emulsifiers.

Still another subject of the invention is a shampoo for a normal scalp,characterized in that it consists of the said basic mixture or of thesaid basic mixture admixed with a lysing or tenderizing agent,preferably with papaw and possibly with an acidifying agent such aslemon juice and with a sufficient amount of shampoo to obtain a washingaction. This shampoo may in addition be admixed with a nutritious mediumcontaining vitamins A, B, C, D, E, PP, amino-acids, calcium and possiblyphospholipids and oligo-elements.

In this case, a preferred nutritive medium consists of the water ofcooking, in preferably slightly mineralized water, of one part by weightof green cabbages and of two parts by weight of spinaches and one addsthree volumes of the said cooking water to one volume of the saidshampoo.

Still another subject of the invention is a pharmaceutical and/orcosmetical composition called dermatological composition No. 2 fortreating the slight states of psoriasis, acne and seborrhea,characterized in that one adds to the said basic mixture whether admixedor not with a tenderizing or lysing agent, preferably with papaw andwith an acidifying agent, preferably lemon juice, an irritating agentand possibly a nutritious medium containing vitamins A, B, C, D, E, PP,amino-acids, calcium and possibly phospholipids and oligo-elements.

A preferred dermatological composition No. 2 of the invention ischaracterized in that the said irritating agent consists of greenpimentos or red peppers and in that the said nutritious medium consistsof the water of cooking, in preferably slightly mineralized water,either of green cabbages or of a mixture M of green cabbages and ofgreen salads with thick leaves, preferably lattuce and of raw beetrootsand in that one adds three parts by volume of the said cooking water toone volume of the said basic mixture whether admixed or not with alysing agent or with an acidifying agent.

In this case, the said irritating agent consists of the cooking water ofthree green pimentos or red pimentos having a length of about 4 to 20 cmand the said nutritive agent or the said cooking water is obtained bycooking in one litre of preferably slightly mineralized water, either ofgreen cabbages only or of about 80 g of green cabbages, 50 g of greensalads with thick leaves and 100 g of beetroots.

The invention also proposes a pharmaceutical and/or cosmetic compositionfor the treatment in particular of acne, of seborrhea, of eczema and ofpsoriasis, characterized in that one provides a mixture (A) of the saidbasic mixture whether admixed or not with a lysing agent, preferablywith papaw and with an acidifying agent, preferably lemon, with thedermatological composition No. 2 in combination with a pharmaceuticallyand/or cosmetically acceptable excipient such as a preservative or ageller and/or thickener for an application as a cream or as a lotion.

This composition is particularly characterized in that the mixture (A)consists of one third by volume of the said basic mixture whetheradmixed or not with a lysing or tenderizing agent, preferably withpapaw, with an acidifying agent, preferably lemon juice and with twothirds by volume of the dermatological composition No.2.

A particular pharmaceutical composition for the treatment of psoriasisis a composition in which the mixture A consists of one third by volumeof the basic mixture admixed with papaw and with two thirds by volume ofthe dermatological composition No. 2.

Another particular pharmaceutical composition for the treatment ofeczema is a composition in which the mixture (A) consists of one sixthby volume of the basic mixture whether admixed or not with a lysing ortenderizing agent, preferably with papaw and an acidifying agent,preferably lemon juice and with five sixth by volume of thedermatological composition No. 2.

A pharmaceutical and/or cosmetic composition for the treatment of acneis a composition in which the mixture (A) consists of two thirds byvolume of the said basic mixture whether admixed or not with a lysing ortenderizing agent, preferably with papaw and with an acidifying agent,preferably lemon juice, is one third by volume of the dermatologicalcomposition No. 2.

Another particular pharmaceutical and/or cosmetic composition for thetreatment of seborrhea and/or of psoriasis of the scalp is a compositionconsisting of the mixture A in combination with a sufficient amount ofshampoo to obtain a washing action. Preferably the said mixture Aconsists of one third by volume of the basic mixture admixed with papawand of two thirds by volume of the dermatological composition No. 2.

The invention has also as its subject the method of manufacture of suchin particular pharmaceutical and/or cosmetic and/or dermatologicalcompositions, the method being of the type consisting in crushing andmixing together the starting ingredients, in letting them reactchemically and then in filtrating the crushed mixture thus obtained toobtain on the one hand a solid and on the other hand a liquid,characterized in that the starting ingredients comprise apples, tomatoesand possibly a lysing agent and an emollient agent.

The use of a mixture of apples, tomatoes for the manufacture of apharmaceutical and/or dermatological composition for the treatment ofacne, of seborrhea, of psoriasis and of eczema falls also within thescope of the invention.

The invention will be better understood and further objects,characteristics, details and advantages thereof will appear more clearlyin the course of the explanatory description which will follow.

The present invention is quite at first based upon the surprisingdiscovery that:

a) the mixture by approximately equal weights of preferably green oryellow crushed apples and of also crushed raw tomatoes causes aspontaneous chemical reaction which lasts about 24 hours and whichresults in a heat evolution as well as in surprising properties for themixture after the end of the chemical reaction;

b) the juice extracted from this mixture exhibits in an unexpectedmanner a stimulating and regenerating activity of the skin.

This activity appears in particular in the following form: a few minutesafter the coating of the face of an individual with the juice extractedfrom a mixture in suitable proportions of tomatoes, apples, a strongfeeling of heat is felt, a blotch appears and grows; after about twentyminutes, the blotch and the heat gradually decrease and then cease forleaving a feeling of freshness and of well-being. By then rinsing theface with water, the dead cells of the epidermis are eliminated. Theintensity of the phenomenon and its duration depend on the type of skinand on the number of treatments undergone by the individual.

However since this juice is particularly active, one may add to themixture of tomatoes, apples, a gelling and/or thickening agent and anemollient agent.

The preferred gelling agent here is peach or kaki, which fruits are bothrich with pectin of which the gelling properties are known but of courseany other gelling and/or thickening agent which will appear to theskilled man as suitable could also be used here, such as the gelsusually known in cosmetics or hyaluronic acid also used in cosmetics.

The preferred emollient agent here is the cucumber, but of course anyother emollient agent which will appear to the man skilled in the art asbeing suitable could also be used here.

One assumes that the activity of the juice extracted from this mixtureof apples and tomatoes, admixed with the emollient agent, which juiceone will call here basic mixture in the following, is due among othersto the spontaneous chemical reaction and to the presence of acids offruits, of vitamin A, vitamin PP, vitamin E.

To facilitate the application and still further improve the comfort ofthe individual this mixture may be integrated into a cosmetically orpharmaceutically acceptable excipient.

This basic mixture may be completed with other plants or substances forhaving either less strong effects than those of the basic mixture andpermitting in particular to provide bracing lotions and shampoos or onthe contrary stronger effects in particular for being able to providethe effect previously described in depth, i.e. in the derm and no longerat the surface of the skin only.

This action in depth may be obtained through addition to the basicmixture of crushed papaws. Here again one assumes that the papawperforms the function of an agent tenderizing the epidermis or the derm.One may also use vegetable products known for their digestive andtenderizing properties for meat, such as the pine-apple, the latex ofthe fig tree as a substitution for the papaw or chemically pure orrefined products contained in the papaw, the pineapple, the latex of thefig tree such as papain, chimopapain, bromelin, pepsin or trypsin.

The ratios of the weights of all the vegetables entering the differentcompositions described here are not critical for observing the effectbut for having a maximum intensity of this effect and for not dependingon compositions of each plant which vary in an appreciable manner fromone batch to the other one as every natural product, the followingproportions in percentages by weight with respect to the weight of thefinal mixture to be obtained are particularly preferred:

a) in the case of a basic mixture which does not integrate any gellingand/or thickening agent or emollient agent, one should take equivalentrates of apples and of tomatoes;

b) in the case of a basic mixture integrating a peach-based orkaki-based gelling agent, one should take between 35 and 40% of peachesor kakis, between 30 and 35% of apples and about 30% of tomatoes inpercentages by weight with respect to the weight of the final mixture tobe obtained;

c) in the case where one wants to obtain a lenitive and emollient actionin particular with cucumber, one should take between 25 and 30% ofpeaches or kakis, between 20 and 25% of apples, between 20 and 25% oftomatoes and between 20 and 25% of cucumbers.

The mixture obtained from these vegetables is provided in a simplemanner at ambient temperature and by using food treatment techniquesfruits and vegetables are cut to pieces with the skin.

The mixture thus obtained is then chopped up and then blended in analimentary mixer. This mixture is then filtrated on a filter the meshdiameter of which is 0.5 mm or less for extracting the liquid.

Although the most active part be the liquid, one may not filtrate thecrushed mixture and use it as such as the basic mixture as defined here.

To obtain the stability in the time, a cosmetically and/orpharmaceutically acceptable preservative should be added.

The liquid or basic mixture thus obtained becomes really active after 24h only after the end of the preparation.

This basic mixture may be used by way of an application every five daysat a maximum with an effect of desquamation, making firmer andregeneration of the skin, preventing off the wrinkles and attenuation ofthe existing wrinkles and it may serve for preparing other compositions.

Thus one will be able to add to this basic mixture an acidifying agent.A preferred acidifying agent is lemon juice in view of its known actionson the skin: action of discoloration of the skin, cleaning of the fattyskins, making the skin and the nails firmer. But any other acidifyingagent known to the man skilled in the art will also be suitable.

One will also be able to add a nutritious medium containing vitamins A,B, C, D, E, PP, calcium, amino-acids, possibly phospholipids andoligo-elements such as iron, copper, manganese, sulphur, phosphorus etc.

A preferred nutritious medium consists of the water of the cooking ofsome vegetables.

To obtain this cooking water, the use of weakly mineralized water issufficient for carrying out the cooking. It is not useful to usedistilled water, thereby further simplifying the carrying out of theinvention. And this is an additional advantage of the invention.

One will now describe by way of examples only given as being indicativeonly and not limiting, applications of the said basic mixture either ornot admixed with an acidifing agent and a tenderizing or lysing agentand/or an irritant agent.

One should recall that in these examples too, the proportions by weightor by volume are not critical but proportions close to those stated arehowever recommended.

With closely related proportions, one understands a variation of aboutplus or minus 30% with respect to what is specified.

EXAMPLE 1

Body lotion for making the skin firmer and eliminating the dead cells.

To obtain this body lotion, one blends one volume of the basic mixtureeither admixed or not with lemon juice, with three volumes of the waterof the cooking of a mixture of green cabbages and of green salads withthick leaves, preferably lattuces.

Advantageously to obtain the cooking water in question, one will cause100 g of green cabbages and 100 g of green salads with thick leaves toboil in one litre of weakly mineralized water for 20 mn.

One may add to this body lotion a cosmetically acceptable preservativeand/or gelling and/or thickening agent as well as fats and water/fatsemulsifiers.

If one desires an action more in depth, one may also add crushed papawor other lysing agents.

EXAMPLE 2

cosmetic composition for the regeneration of the skin and making itfirmer, the preventing of wrinkles and the attenuation of the existingwrinkles.

The basic mixture either admixed or not with papaw and/or lemon juice isa mixture with a cosmetically acceptable thickener and/or preservativeand/or water and/or fats and/or hydrating fats for an application as acream or as a mask.

One may in particular use as an excipient, cosmetic creams of the typeof those sold on the market.

EXAMPLE 3

Lotion permitting to increase the tolerance to the sun when it isapplied before exposure to the sun and to alleviate and to relieve thepain pursuant to an excessive exposure to the sun.

One volume of the said basic mixture either or not admixed with papawand/or lemon juice is blended with one volume of the water of thecooking, in weakly mineralized water, of a mixture in equal proportionsby weight of beetroots, green cabbages and spinaches.

One should add to the mixture called mixture B thus obtained one volumeof carrot juice equal to 20% of the volume of this mixture B.

Advantageously, the cooking water is obtained by causing 100 g of rawbeetroots, 100 g of green cabbages and 100 g of spinaches to boil for 20mn in one litre of weakly mineralized water.

One may possibly add fat and water/fat emulsifying agents, hydratingagents or even a hydrating cream of the type of those sold on the marketto obtain at the same time a complementary effect of hydratation.

One may as previously add to this lotion preservatives and thickeners tofacilitate and improve the application of this lotion.

The carrot juice gives the skin a coloration but this is not its soleeffect. It acts in synergy with the basic mixture and as an agentcontaining compounds of the vitamin A such as the vitamin A and theprovitamin A. Thus any other agent supplying these compounds could beused here.

In particular, the previous lotion exhibits the inconvenience of riskingto stain the garments. An alternative composition which does not exhibitthis inconvenience consists in replacing the carrot juice with greencabbage juice which is almost as rich in beta-carotene as carrot juice.

EXAMPLE 4

Shampoo for Normal Scalp.

To one volume of the basic mixture either or not admixed with papawand/or lemon juice, one adds three volumes of water of the cooking ofone part by weight of green cabbages and of two parts by weight ofspinaches. One then introduces a sufficient amount of shampoo to obtaina washing action.

Preferably the cooking water is obtained by causing 100 g of greencabbages and 200 g of spinaches to boil for 20 mn in one litre of weaklymineralized water. One blends three volumes of this cooking water withone volume of the basic mixture. One possibly adds 100 to 140 drops oflemon juice to about one litre of the previous mixture.

One adds shampoo sufficiently for having a washing action. Oneunderstands here with a normal scalp a scalp exhibiting no excess ofseborrhea or dermatological diseases.

EXAMPLE 5

Cosmetic and/or pharmaceutical composition called dermatologicalcomposition No. 1 for attenuating and/or eliminating the slight statesof seborrhea and acne.

One blends in a mixer two thirds by weight of the basic mixture eitheror not admixed with lemon juice, with one third by weight of papaw.

The papaw is cut up with the skin and the flesh while not taking theseeds.

EXAMPLE 6

Cosmetic and/or pharmaceutical composition called dermatologicalcomposition No. 2 for attenuating and/or eliminating the slight statesof psoriasis, of acne and of seborrhea.

One mixes three volumes of the water of the cooking of three cut greenor red pimentos with a length comprised between about 4 cm and about 20cm and of a mixture of green cabbages, green salads with thick leaves,preferably lattuce, raw beetroots and of green or red pimentos with onevolume of the dermatological composition No. 1.

Preferably one will obtain the aforesaid cooking water by causing threecut up green or red pimentos with a length comprised between about 4 cmand about 20 cm and 80 g of green cabbages, 50 g of green salads withthick leaves, 100 g of raw beetroots to boil for 25 mn in one litre ofweakly mineralized water.

The pimentos here perform the function of an irritant agent. As such,any irritant agent, which would appear to the man skilled in the art,could be used. In particular, any substance providing capsaicin or amember of the family of the capsaicinoids could be used.

One thus obtains a composition which, in an unexpected manner, has aselective desquamation effect limited to the horny skin or to the skinaffected by diseases such as psoriasis, acne and seborrhea.

The successive applications of the dermatological composition No. 2 ontothe non healthy skin result in a gradual desquamation, the effect ofeach application being limited to an external layer of the skin. Theapplication of the dermatological composition No. 2 onto the sound skinon the contrary has a slightly irritating effect which however resultsin no desquamation.

The repeated applications of the dermatological composition No. 2 ontothe sound skin exhibit no inconveniences as long as they are notextended and systematical.

By making mixtures of the dermatological compositions No. 1 and No. 2,one obtains compositions which in an unexpected manner permit to treatdisorders or diseases of the skin such as acne, seborrhea, eczema andpsoriasis.

The mixtures of the dermatological compositions No. 1 and No. 2 mayeither be made in advance in a fixed manner or on the contrary in anadvantageous manner developed in the course of time to promote at firstone type of effect and then the other one or originate from alternateapplications of both compositions.

EXAMPLE 7

Pharmaceutical composition for the treatment of psoriasis.

A particularly preferred composition for the treatment of psoriasisconsists of a mixture of one third by volume of the dermatologicalcomposition No. 1 and of two thirds by volume of the dermatologicalcomposition No. 2.

Preferably this mixture is applied for three days per week twice one anda half hour onto the affected parts. Here also to facilitate theapplication and improve the comfort of the patient, this compositioncould be admixed with a thickener and/or a preservative.

EXAMPLE 8

Pharmaceutical composition for the treatment of eczema.

A preferred composition for treating eczema consists of a mixture of onesixth by volume of the dermatological composition No. 1 with five sixthby volume of the dermatological composition No. 2.

Preferably this composition is applied for three days per week twice oneand a half hour onto the affected parts.

Once more, this composition could be mixed with an excipient such as athickener, a preservative etc. to improve the comfort of the patient andto facilitate the application as a cream or as a mask.

EXAMPLE 9

Composition for the treatment of acne.

A preferred mixture permitting to treat acne consists of two thirds byvolume of the dermatological composition No. 1 and of one third byvolume of the dermatological composition No. 2 either or not admixedwith already cited excipients.

Preferably this composition is applied for three days per week twice oneand a half hour onto the affected parts.

EXAMPLE 10

Pharmaceutical and/or cosmetic composition for the treatment ofseborrhea and/or psoriasis of the scalp.

This composition consists of a mixture of one third by volume of thedermatological composition No. 1 and of two thirds by volume of thedermatological composition No. 2 to which one adds shampoo sufficientlyfor obtaining a washing action.

This composition is particularly interesting since it permits to obtaina treatment of the scalp easy and simple to be used since it consists inmerely washing the hair on an average three times a week.

The cosmetic and/or pharmaceutical in particular dermatologicalcompositions according to the present invention may be prepared in formssuiting various modes of administration. In particular they may presentthemselves in a form intended for the superficial administration ontothe skin or the scalp such as a cream, a milk, a gel or a lotion inorder to stimulate and to regenerate or to treat the skin.

A non negligible advantage of the invention is to provide pharmaceuticaland/or cosmetic compositions which are preserved for a sufficiently longduration (about 18 months at ambient temperature and light). This limitsmost of the storage and stocking problems without having to provide theisolation of any active substance, these methods of isolation in generalbeing long and expensive.

The invention is of course not at all limited to the embodimentsdescribed and illustrated which have been given by way of examples only.

Thus for example it will allow to obtain a composition permitting toremove the blotches, onsets of eczema and other skin problems of theinfants without causing traumatizing and dangerous chemical compounds tointervene on such subjects.

It will likewise allow to remove the blisters occurring pursuant tosmall burns such as the usual domestic burns if the mixture is appliedonto the burned skin very quickly after the burn.

It will also permit to accelerate the healing of the wounds resultingfrom cuts or from localized frictions by applying the mixture.

Likewise although in the examples, one has expressly made reference tothe papaw, it is well understood that any other tenderizing or lysingagent could be used in an equivalent manner.

In the same fashion, although one has described compositions containingthe water of the cooking of some particular vegetables, it should bewell understood that any other nutritious medium containing vitamins A,B, C, D, E, PP, calcium, amino-acids and possibly phospholipids andoligo-elements could be used in an equivalent manner.

Even more, some compositions of the invention could be used asalimentary compositions to obtain a systemic effect.

On the contrary, the invention comprises all the equivalents of themeans described as well as their combinations if the latter are carriedout according to its gist.

What is claimed is:
 1. A method for manufacturing a compositioncomprising crushing tomatoes and apples, mixing the crushed tomatoes andapples together in a weight ratio of tomatoes to apples between 0.8 and1.25 to produce a mixture (M), allowing the mixture (M) to stand forabout twenty-four hours, and filtering the mixture (M) after thestanding for about twenty-four hours to produce a filtered liquid as thecomposition.
 2. The method according to claim 1, including diluting themixture (M) and adding an emollient.
 3. The method according to claim 2,wherein the emollient is cucumber.
 4. The method according to claim 3,including blending a gelling agent with the mixture (M).
 5. The methodaccording to claim 4, wherein the gelling agent is one of peach andpersimmon.
 6. The method according to claim 4, wherein the gelling agentis a cosmetically and pharmaceutically acceptable agent.
 7. The methodaccording to claim 5, wherein the composition includes between 35 and40% of one of peaches and persimmons, between 30 and 35% of apples, andabout 30% of tomatoes, by weight.
 8. The method according to claim 5,wherein the composition consists of between 25% and 30% of one ofpeaches and persimmons, between 20 and 25% of apples, between 20 and 25%of tomatoes, and between 25 and 30% of cucumbers by weight.
 9. Themethod according to claim 1 including adding one of a tenderizing andlysing agent to the mixture (M).
 10. The method according to claim 9,including adding a lysing agent wherein the lysing agent is selectedfrom the group consisting of papaw, papain, chimopapain, trypsin,pineapple, latex of the fig tree, and pepsin.
 11. The method accordingto claim 9, including adding a tenderizing agent wherein the tenderizingagent is papaw.
 12. The method according to claim 11, including mixingabout one third by weight of papaw with about two thirds by weight ofthe mixture (M).
 13. The method according to claim 1, including addingan acidifying agent to the mixture (M).
 14. The method according toclaim 13, wherein the acidifying agent is lemon juice.
 15. The methodaccording to claim 1, including adding an irritant agent.
 16. The methodaccording to claim 15, wherein the irritant agent is capsaicin.
 17. Themethod according to claim 15, wherein the irritant agent is water inwhich pimentos have been cooked.
 18. The method according to claim 1,including adding a nutritious and protective medium containing vitaminsA. B, C, D, E, PP, calcium, beta-carotene, amino-acids, carbohydrates,sterols, purins, fatty acids, and, optionally, phospholipids andoligo-elements such as iron, copper, manganese, sulphur, phosphorus, andiodine to the mixture (M).
 19. The method according to claim 18, whereinthe nutritive and protective medium includes one of cabbage juice andwater in which cabbages have been cooked.
 20. The method according toclaim 18, wherein the nutritive, and protective medium consists of waterin which green cabbages and green salad with thick leaves, such aslettuce, have been cooked.
 21. The method according to claim 19,including mixing together one volume of the composition obtainedaccording to claim 17, and three volumes of the water.
 22. A body lotioncomprising the composition obtained by the method according to claim 18.23. A shampoo comprising the composition obtained by the methodaccording to claim
 1. 24. A shampoo comprising the composition obtainedby the method according to claim 18.